Prana Biotechnology trials new drug for Dementia sufferers.

The Good News and the bad news for the elderly (and the government)

The good news for the elderly is that we are living longer, well into the early eighties, with the expectation of living two decades in retirement.

The bad news is that the incidences of degenerative diseases such as dementia are becoming more prevalent now that we are living longer.

These trends are important not only for individual sufferers, and their care-providing families, but also for the government and other providers of services to the  elderly.

It follows that the practicality of lifting the retirement age in Australia from 65 years to 70 should be questioned. Long before Alzheimer’s is obvious to all, impairment of memory and manual skills may limit work opportunities..

Medical advances which have improved longevity, have not necessarily extended working life.  Any treatment which can arrest or reverse the effects of dementia could bring enormous economic benefits for government, and command a significant price premium. This is the challenge facing Prana Biotechnology.

The dreaded Dementias

Brain function deteriorates with time. This is accelerated by diseases which affect the brain, such as arteriosclerosis and Parkinson’s disease. Sufferers care little whether there is a demonstrable cause for their loss of memory, and impairment of thought and function, or the cause is not obvious as it is in Alzheimer’s disease. Many patients may have features of both.

There are two authoritative websites that should be referenced for information about Alzheimer’s and other Dementias.

1. Health In Site, a government sponsored website with information on health issues, including Alzheimer’s disease.

Facts & figures  http://www.healthinsite.gov.au/topic/alzheimers-disease

  • In 2011, there were an estimated 298,000 people with dementia in Australia. Dementia is a leading cause of death, accounting for 6% of all deaths in 2010.

  • Alzheimer’s disease is most common in people over 65 years of age, and affects slightly more women than men. However, there were an estimated 23,900 Australians who had early-onset dementia under the age of 65 in 2011.

  • Dementia poses a substantial challenge to health, aged care and social policy. Based on projections of population ageing and growth, the number of people with dementia will reach almost 400,000 by 2020.

2. The Website of Alzheimer’s Australia

http://www.fightdementia.org.au/understanding-dementia/alzheimers-disease.aspx

Quick Facts

  • Alzheimer’s disease damages the brain, resulting in impaired memory, thinking and behaviour
  • The biggest risk factor for having Alzheimer’s disease is increasing age, with 1 in 4 people over 85 having dementia
  • Sporadic Alzheimer’s disease can affect anyone of any age
  • Familial Alzheimer’s disease is a very rare genetic condition, with an age of onset of less than 65 years

What is Alzheimer’s Disease?

Alzheimer’s disease is the most common form of dementia, affecting up to 70% of all people with dementia. It was first recorded in 1907 by Dr Alois Alzheimer. Dr Alzheimer reported the case of Auguste Deter, a middle-aged woman with dementia and specific changes in her brain. For the next 60 years Alzheimer’s disease was considered a rare condition that afflicted people under the age of 65. It was not until the 1970s that Dr Robert Katzman declared (rather boldly at the time) that senile dementia and Alzheimer’s disease were the same condition and that neither were a normal part of aging.

Alzheimer’s disease can be either sporadic or familial.
Sporadic Alzheimer’s disease can affect adults at any age, but usually occurs after age 65 and is the most common form of Alzheimer’s disease.
Familial Alzheimer’s disease is a very rare genetic condition, caused by a mutation in one of several genes. The presence of mutated genes means that the person will eventually develop Alzheimer’s disease, usually in their 40’s or 50’s.

The Healthy Human Brain

The whole brain is fed and provided with oxygen by a complex network of arteries, veins and capillaries. This vascular network is strictly controlled and segregates the brain from the rest of the blood stream. The blood brain barrier protects the brain from infection, but consequently if the brain does become infected it is difficult to treat, as many antibiotics are too large in their molecular structure to cross the barrier. This is also a major problem when finding agents to treat Alzheimer’s disease, as they must pass this barrier to target the brain.

Behind the ears and temples are the temporal lobes of the brain. These regions process speech and working memory, and also ‘higher’ emotions such as empathy, morality and regret. Beneath the forebrain are the more primitive brain regions such as the limbic system. The limbic system is a structure that is common to all mammals and processes our desires and many emotions. Also in the limbic system is the hippocampus – a region that is vital for forming new memories.

The cerebellum is at the back of the brain, which stores our muscle memory so we can do things without thinking – such as riding a bike. The midbrain and brain stem are the most primitive regions of the brain. They control bodily functions such as heart rate and digestion and act as an interface between the spinal cord and the rest of the brain.

All these complex tasks are mediated by the connections between the brain cells (neurons) called synapses. In the adult human brain there are around 100 billion brain cells, each connected to its neighbours by 5-10,000 synapses.

Our brains form a million new connections – a million new synapses – every second we are alive. The pattern and strength of the connections is constantly changing and no two brains are alike.

It is in these changing connections that memories are stored, habits learned and personalities shaped, by reinforcing certain patterns of brain activity, and losing others.

Brain cells communicate though synapses in a variety of ways. Signals pass move across the synapse in the form of chemicals that are known as neurotransmitters. Neurotransmitters a passed from one brain cell, across the synapse (connection) and to the receiving brain cell, which collects the neurotransmitter with a receptor. The receiving cell can then send out another burst of neurotransmitters to other brain cells to pass the message on.

The Brain with Alzheimer’s Disease

Going back to the 1900s, Dr Alzheimer examined the brain of his patient, Mrs Deter, upon her death. He found shrinking of the outer layer of the brain or cortex – the region of the brain involved in memory, language and judgment. We know that the so called shrinking of the brain is caused by the death of the brain cells.

Dr Alzheimer also found two types of deposits in Deter’s brain. One kind was found outside the brain cells, which are known plaques and the other type of deposit was found inside brain cells known as “neurofibrillary tangles. These plaques impair synapses so signals cannot pass between brain cells. Tangles kill brain cells by preventing the normal transport of food and energy around the brain cell.

As brain cells die the brain shrinks, which can be detected using imaging such as magnetic resonance imaging (MRI).

The outer part of the brain is usually the area affected first by the disease. Short-term memory loss is therefore one of the first symptoms of Alzheimer’s disease. But as the disease progresses to deeper parts of the brain, long-term memory is also lost. The disease also affects many of the brain’s other functions and consequently, many other aspects of behaviour are disturbed.

Apart from the few individuals with Familial Alzheimer’s disease, it is not known why one individual gets Alzheimer’s disease late in life and another does not. Scientists are investigating what triggers the formation of plaques and tangles and about other chemical changes that damage brain cells in Alzheimer’s disease.

A variety of suspected causes are being investigated including factors in the environment, biochemical disturbances and immune processes. The cause may vary from person to person and may be due to one factor or a number of factors.

Symptoms of Alzheimer’s disease

In the early stages the symptoms of Alzheimer’s disease can be very subtle. However, it often begins with lapses in memory and difficulty in finding the right words for everyday objects.

Other symptoms may include:

  • Persistent and frequent memory difficulties, especially of recent events
  • Vagueness in everyday conversation
  • Apparent loss of enthusiasm for previously enjoyed activities
  • Taking longer to do routine tasks
  • Forgetting well-known people or places
  • Inability to process questions and instructions
  • Deterioration of social skills
  • Emotional unpredictability

Symptoms vary and the disease progresses at a different pace according to the individual and the areas of the brain affected. A person’s abilities may fluctuate from day to day, or even within the one day, becoming worse in times of stress, fatigue or ill-health.

How does Alzheimer’s disease progress?

The rate of progression of the disease varies from person to person.

However, the disease does lead eventually to complete dependence and finally death, usually from another illness such as pneumonia. A person may live from three to twenty years with Alzheimer’s disease, with the average being seven to ten years.

How is Alzheimer’s disease diagnosed?

There is currently no single test to identify Alzheimer’s disease. The diagnosis is made only after careful clinical consultation.

The clinical diagnosis might include:

  • A detailed medical history
  • A thorough physical and neurological examination
  • A test of intellectual function
  • Psychiatric assessment
  • A neuropsychological tests
  • Blood and urine tests
  • Lumbar puncture for cerebral spinal fluid tests
  • Medical imaging (MRI, PET)

These tests will help to eliminate other conditions with similar symptoms such as nutritional deficiencies or depression. After eliminating other causes, a clinical diagnosis of Alzheimer’s disease can be made with about 80% to 90% accuracy if the symptoms and signs are appropriate. The diagnosis can only be confirmed after death by examination of the brain tissue.

It is important to have an early and accurate diagnosis to determine whether a treatable condition other than Alzheimer’s disease, is causing the symptoms. If Alzheimer’s disease is diagnosed, medical treatment and other assistance can be discussed.

Is there treatment available?

At present there is no cure for Alzheimer’s disease. However, one group of drugs called cholinergeric drugs appears to be providing some temporary improvement in cognitive functioning for some people with mild to moderate Alzheimer’s disease.

Drugs can also be prescribed for secondary symptoms such as restlessness or depression or to help the person with dementia sleep better.

Community support is available for the person with Alzheimer’s disease, their families and carers. This support can make a positive difference to managing dementia. Alzheimer’s Australia provides support, information and counselling for people affected by dementia. Alzheimer’s Australia also aims to provide up-to-date information about drug treatments.

For more information contact the National Dementia Helpline on 1800 100 500.

Enter Prana Biotechnology

This biotech company was floated on the Australian Stock Exchange at $1 in March 2000. Two years later it was listed on the NASDAQ exchange in the USA. The principle product is PBT2 for treatment of Alzheimer’s disease.

The long-term view from a monthly chart:

Renewed interest into PBT

Renewed interest into PBT

  • The second listing of the shares in the USA stimulated interest in the stock  climaxing at $2.78 in March 2002.
  • Over the next year the share-price fell away to about 50 cents.
  • Between 2003 and  2012 there was little or no interest in the stock which sunk as low as 11-12 cents.
  • Signs of life emerged in 2013 manifest in increased volume of shares traded, and a rising share price from 20 cents in January to 85 cents in December.

Short-Term Picture from a 12 month daily chart

Prana's share-price jumps three-fold in just 4 months.

Prana’s share-price jumps three-fold in just 4 months.

Observations made:

  • There are five levels of support/ resistance, milestone targets which have been progressively reached.
  • Base line support at 20 cents
  • From August to the end of October, resistance becoming support at 37 cents.
  • Resistance becoming support at 70 cents following retracement from an interim high at 85 cents.
  • A second leg impulsive move higher with uni-directional trending from 70 cents to a high on Jan 31 of $1.27
  • In the steep trending of the last two weeks the share-price has gapped higher at the open on a daily basis.

Conclusions

There has been committed buying, irrespective of price in the past four months, peaking in the last month. The total increase in the past twelve months is six-fold! Incredible! After such a meteoric rise one would expect profit taking and a retracement.

However, it is quite likely that management will take advantage of the present strength of the share-price by announcing a capital raising.

The jump in the share-price has been attributed to positive experimental results of PBT2 on age-related changes in mice brains.

Disclaimer

The opinions expressed above should not be relied on in making investment decisions. Rather the advice of a profession adviser or broker specific to your requirements should be sought.

 



Categories: Chart Analyses, Health and well-being, Technical Analysis, Trading opinion

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